have opened as a 2-point home underdog against the Indianapolis Colts (-2). This might be the closest the Titans are in an opening odds post for the rest of the season. It should be noted that Tennessee has won 4 straight games at Nissan Stadium while not winning anywhere else in the world over the last year.
Indianapolis comes into this game at 6-5 having won three straight after losing the three before that. Gardner Minshew has kept his team in the hunt after he took over for Anthony Richardson - who was lost for the year the first time these two teams met.